Author

L. Michon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Organism:yeast· 5 Research Focus:development & morphogenesis· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

S. G. Martin· 4 shared I. Billault-Chaumartin· 2 shared O. Muriel· 2 shared A. Archetti· 1 shared A. Karabajakian· 1 shared A. Mock· 1 shared A. Shnerb· 1 shared B. Joshua· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersCell Biology

S. G. Martin

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Author profile →

6 papers

Recent·Most cited

Condensation of the fusion focus by the intrinsically disordered region of the formin Fus1 is essential for cell-cell fusion

I. Billault-Chaumartin, O. Muriel, L. Michon, S. G. Martin

This study shows that the intrinsically disordered region of Fus1 mediates condensation of the actin fusion focus, essential for yeast gamete fusion and preventing cell lysis.

Current Biology · Nov 1, 2022Peer-reviewedCell Biology

The actin assembly requirements of the formin Fus1 to build the fusion focus

I. Billault-Chaumartin, L. Michon, C. A. Anderson, S. E. Yde, C. Suarez, J. Iwaszkiewicz, V. Zoete, D. R. Kovar, S. G. Martin

This study investigates how the nucleation and elongation rates of the formin Fus1 affect the formation of the actin fusion focus in fission yeast, showing that native rates are optimal for this structure.

bioRxiv · Mar 24, 2022Cell Biology

MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer

M. Prasad, J. Zorea, S. Jagadeeshan, A. Shnerb, J. Bouaoud, L. Michon, O. Novoplansky, M. Badarni, L. Cohen, K. Yagodayev, S. Tzadok, B. Rotblat, L. Brezina, A. Mock, A. Karabajakian, , M. Elkabets

This study shows that MEK1/2 inhibition temporarily improves the tumor immune microenvironment, enhancing immunotherapy effectiveness in head and neck cancer by reducing suppressive myeloid cells and boosting CD8+ T cell activity.

bioRxiv · Aug 22, 2021Cancer Biology

Ultrastructural plasma membrane asymmetries in tension and curvature promote yeast cell fusion

O. Muriel, L. Michon, W. Kukulski, S. G. Martin

This study reveals asymmetric plasma membrane conformations in yeast cell fusion, driven by turgor pressure and exocytosis/endocytosis ratios, which facilitate cell fusion.

bioRxiv · Mar 18, 2021Cell Biology

Multi-phosphorylation reaction and clustering tune Pom1 gradient mid-cell levels according to cell size

V. Gerganova, C. Floderer, A. Archetti, L. Michon, L. Carlini, T. Reichler, S. Manley, S. Martin

The paper shows that Pom1 gradients in S. pombe cells are regulated by multi-phosphorylation and clustering, adjusting mid-cell levels based on cell size.

bioRxiv · Feb 11, 2019Cell Biology

Feedback inhibition of Ras activity coordinates cell fusion with cell-cell contact

L. Merlini, B. Khalili, O. Dudin, L. Michon, V. Vincenzetti, S. G. Martin

The paper shows that Ras activity feedback inhibition coordinates cell fusion with cell-cell contact in fission yeast.

bioRxiv · Jun 19, 2017Cell Biology