D. Kong

Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

This paper introduces DRAM, a method for transcriptome-wide m5C detection using deaminase and reader proteins, showing high overlap with BS-seq data and supporting low-input RNA.

Nuclear receptor E75/NR1D2 drives tumor malignant transformation by integrating Hippo and Notch pathways

The paper shows that E75/NR1D2 integrates Hippo and Notch pathways to drive tumor malignancy in response to hormone inhibition.

Macrophages facilitate interclonal cooperation-induced tumor heterogeneity and malignancy by activating the innate immune signaling

This study shows that macrophages in Drosophila tumors promote heterogeneity and malignancy by activating innate immune signaling through the Toll pathway.

The structure and diversity of the bacterial community in the overlying water of the Yangzong Lake in Yunnan

This study analyzes bacterial community structure and diversity in Yangzong Lake overlying water using high-throughput sequencing, finding variations in physicochemical factors and dominant taxa across sampling sites.

Engineering One-Signal Activated TILs with CD3ζ-CD28 Chimeras Optimizes the Antitumor Efficacy of TIL-Based Immunotherapy

This paper engineers one-signal-activated TILs with CD3ζ-CD28 chimeras to enhance antitumor efficacy in immunotherapy.

Structure of scavenger receptor SCARF1 and its interaction with lipoproteins

This study determines the structure of SCARF1 and identifies its ligand recognition mechanism, revealing key residues and shared binding sites for modified LDLs and bacterial teichoic acids.

Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation

The paper shows CAM-A modulators eliminate HBV-infected hepatocytes with high core antigen levels via apoptosis, dependent on de novo core protein translation.

Aptamer-antibody chimera sensors for sensitive, rapid and reversible molecular detection in complex samples

This paper introduces PANDAS, a sensor combining antibodies and aptamers for sensitive, rapid, and reversible molecular detection in complex samples, achieving 100-fold improved sensitivity for thrombin detection.

Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins

The paper investigates the role of Drosophila Polychaetoid/ZO-1 in strengthening cell junctions under tension and its distinct localization compared to core adherens junction proteins.

Novel leaf-root coordination driven by leaf water storage tissues in mangroves

This study identifies a unique leaf-root coordination mechanism in mangroves driven by leaf water storage tissues, distinct from non-mangrove plants.

Mechanistic basis for targeting homologous recombination defective liver cancer via synthetic lethality

This study identifies a novel subtype of HRD in HBVHCC caused by CDW19S perturbation and shows it can be targeted therapeutically.

Arabidopsis MLO4 Functions as a Ca2+ Channel Essential for Mechanosensing in Root Tips

This study identifies MLO4 as a Ca2+ channel essential for mechanosensing in Arabidopsis root tips, linking touch stimulation to Ca2+ elevation.

Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects

This study shows peramivir reduces cytokine storm by inhibiting NF-κB activity in macrophages and alleviates lung injury in mice.

MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer

This study shows that MEK1/2 inhibition temporarily improves the tumor immune microenvironment, enhancing immunotherapy effectiveness in head and neck cancer by reducing suppressive myeloid cells and boosting CD8+ T cell activity.

A Bivalent Chromatin Controls Timing of Expression of Camalexin Biosynthesis Genes in Response to a Pathogen Signal in Arabidopsis

The paper identifies a bivalent chromatin state, called a kairostat, that controls the timing of camalexin biosynthesis gene expression in Arabidopsis in response to pathogen signals.

Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures

This study identifies potent non-covalent SARS-CoV-2 PLpro inhibitors that block viral replication in human and monkey cell cultures with low nanomolar potency.

Double Lock of a Potent Human Monoclonal Antibody against SARS-CoV-2

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

Synthetic lethality between TP53 and ENDOD1

This study identifies synthetic lethality between ENDOD1 and TP53, showing that their combined loss causes DNA damage and cell death, suggesting ENDOD1 as a cancer therapeutic target.

Flow-cell based technology for massively parallelcharacterization of base-modified DNA aptamers

This paper introduces a flow-cell based system for high-throughput characterization of base-modified DNA aptamers using a modified Illumina MiSeq instrument.

Procentriole microtubules as drivers of centriole reduplication

The paper investigates how procentriole microtubules drive centriole reduplication, showing that their structural changes lead to centriole disengagement and reduplication during cell cycle arrests.

Girdin: an essential component of pre-replicative complex in human cells

This study identifies Girdin as an essential replication initiation factor in human cells, required for pre-RC assembly by recruiting Cdc6 to DNA origins.

Regulation of Cilia Abundance in Multiciliated Cells

This study shows that centriole and cilia abundance in multiciliated cells is controlled by surface area, not parental centrioles or Plk4.

Arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in low-dose exposed mouse embryonic fibroblast cells

This study shows arsenite exposure reduces p300 and H3K27ac at enhancers in MEF cells, affecting gene expression and potentially contributing to arsenic-related disease.

PLK4 is a microtubule-associated protein that self assembles promoting de novo MTOC formation

The paper shows PLK4 self-assembles into structures that recruit tubulin and form de novo MTOCs in Xenopus extracts.

Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells

This study shows that delta-tubulin and epsilon-tubulin are essential for stable centriole formation and inheritance in human cells by maintaining triplet microtubules.