BioengineeringbioRxivPreprint
Targeted delivery of interferon-gamma by synNotch T cells sensitizes neuroblastoma cells to T cell-mediated killing
F. Iglesias, S. Weston, S. V. Avila…·T. Luetkens
This study develops synNotch T cells that deliver IFN-gamma to neuroblastoma cells, restoring HLA expression and enhancing T cell-mediated killing without increasing immune checkpoints or systemic IFN-gamma.
DOI 10.1101/2022.06.21.496901