Attenuation of polysialic acid biosynthesis in cells by the small molecule inhibitor 8-keto-sialic acid
C. Hunter, Z. Gao, H.-M. Chen, N. Thompson, W. Wakarchuk, m. nitz, S. Withers, L. M. Willis
The paper describes 8-keto-sialic acid as a non-toxic inhibitor that blocks polysialic acid synthesis by terminating chain elongation in cancer and immune cells.
bioRxiv · Sep 2, 2022Biochemistry