H. Wan

MRT-ModSeq - Rapid detection of RNA modifications with MarathonRT

The paper introduces MRT-ModSeq, a method for rapid detection of multiple RNA modifications using MarathonRT, and demonstrates its ability to identify various modifications across RNA transcripts.

Doxorubicin inhibits phosphatidylserine decarboxylase and confers broad-spectrum antifungal activity

The paper shows doxorubicin inhibits MoPSD2, a phosphatidylserine decarboxylase in Magnaporthe oryzae, reducing fungal growth and crop disease severity.

Modernizing the original influenza vaccine to enhance protective antibody responses against neuraminidase antigens

This study enhances influenza vaccine efficacy by improving NA antibody responses through modified virions and recombinant NA proteins in a mouse model.

Improving the preclinical and clinical success rates of LMW drugs depends on radical revisions to the status quo scientific foundations of medicinal chemistry: a case study on COVID Mpro inhibition

This paper argues for a theoretical shift in medicinal chemistry to improve LMW drug success rates by applying Biodynamics to model cellular function and drug action in non-linear dynamic systems.

Brevicidine, a bacterial non-ribosomally produced cyclic antimicrobial lipopeptide with a unique modus operandi

This study investigates brevicidine's antimicrobial mechanism against AMR Gram-negative pathogens and shows its efficacy in a mouse model.

Toward a first principles understanding of the activation and deactivation mechanisms of class A G-protein coupled receptors and voltage-gated cation channels

This paper applies a multi-scale theory to analyze activation and deactivation mechanisms of GPCRs and VGCCs, proposing solvation dynamics as the driving force behind conformational changes.

Extracellular prostaglandins E1 and E2 and inflammatory cytokines are regulated by the senescence program in potentially premalignant oral keratinocytes

This study shows that senescence in premalignant oral keratinocytes increases extracellular prostaglandins E1 and E2 and inflammatory cytokines, which may promote progression to oral SCC through paracrine signaling.

Vaccine Protection Against the SARS-CoV-2 Omicron Variant in Macaques

This study evaluates vaccine efficacy against SARS-CoV-2 Omicron in macaques, finding that both humoral and cellular immune responses are necessary for virologic control.

Solvation dynamics-powered structure and function of multi-molecular cellular systems exemplified by non-equilibrium cereblon-degrader-CK1α ternary complex formation

The paper examines how solvation dynamics power structural and functional dynamics in multi-molecular complexes, exemplified by cereblon-degrader-CK1α interactions.

Immunity to SARS-CoV-2 up to 15 months after infection

This study tracks SARS-CoV-2 immunity in patients up to 15 months post-infection, showing sustained antibody and memory B/T cell responses but reduced neutralization against variants.

General structure-free energy relationships of hERG blocker binding under native cellular conditions

The paper analyzes hERG blocker binding using solvation field principles, showing correlations between solvation costs and blocker potency and safety.

Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery Against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques

This study evaluates the protective efficacy of oral SARS-CoV-2 delivery in rhesus macaques against respiratory challenges, finding limited immunogenicity and partial protection.

Protective efficacy of rhesus adenovirus COVID-19 vaccines against mouse-adapted SARS-CoV-2

This study evaluates the protective efficacy of rhesus adenovirus serotype 52 vaccines against a mouse-adapted SARS-CoV-2 strain, showing robust antibody responses and protection against viral replication and disease.

Comparison of the neuraminidase antigenicity in recently circulating influenza A and vaccine viruses

The paper compares the antigenicity of neuraminidase (NA) from circulating influenza A viruses to vaccine strains, finding antigenic similarity and highlighting C-terminal substitutions affecting H3N2 NA reactivity.

Design of the recombinant influenza neuraminidase antigen is crucial for protective efficacy

This study evaluates how different designs of recombinant influenza neuraminidase (rNA) affect protective efficacy in mice, showing that domain combinations significantly influence immunogenicity and protection.

Balancing the influenza neuraminidase and hemagglutinin responses by exchanging the vaccine virus backbone

The paper shows that exchanging viral backbone genes can increase neuraminidase content in influenza virions, leading to better NA antibody responses in mice.

Persistence of SARS-CoV-2 specific B- and T-cell responses in convalescent COVID-19 patients 6-8 months after the infection

This study tracks SARS-CoV-2 specific B- and T-cell responses in convalescent patients 6-8 months post-infection, finding sustained memory cell responses despite declining antibody levels.

Priority effects dictate community structure and alter virulence of fungal-bacterial biofilms

This study investigates how priority effects and competitive exclusion shape fungal-bacterial biofilm communities and influence virulence in chronic wounds.

Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

This paper develops a two-step model of hERG blocker binding and proposes an improved safety assessment strategy incorporating dynamic occupancy, exposure, and disease factors.

Antibody neutralization of an influenza virus that uses neuraminidase for receptor binding

This study shows that anti-NA antibodies can neutralize influenza viruses that use NA for receptor binding, enabling sensitive detection and escape mutant selection.

Polyploidization enhancing genetic recombination of the ancestral diploid genome in the evolution of hexaploid wheat

This study shows that hexaploidization in wheat enhances genetic recombination of the ancestral diploid genome, increasing evolutionary potential and aiding wheat's global spread.

The desmosomal cadherin Desmoglein-3 regulates YAP and phospho-YAP in keratinocyte responses to mechanical forces

This study shows that Dsg3 regulates YAP and phospho-YAP in keratinocyte mechanotransduction, affecting their response to mechanical forces and nuclear localization.

Proliferative behavior of hematopoietic stem cells revisited: No evidence for mitotic memory

The paper revisits the proliferative behavior of hematopoietic stem cells (HSCs) and finds no evidence for mitotic memory or permanent quiescence after few divisions.

Reconciling simulated ensembles of apomyoglobin with experimental HDX data using Bayesian inference and multi-ensemble Markov State Models

The paper uses Bayesian inference and multi-ensemble Markov State Models to refine simulated ensembles of apomyoglobin with experimental HDX data, improving conformational modeling.

The landscape and diagnostic potential of T and B cell repertoire in Immunoglobulin A Nephropathy

This study analyzes TCRB and IGH repertoires in IgAN patients to identify non-invasive biomarkers for diagnosis.

WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death

This study identifies WDR45's role in neurodegeneration by showing its regulation of ER homeostasis and neuronal death through autophagy defects.