ImmunologybioRxiv
Across functional boundaries: making non-neutralizing antibodies to neutralize HIV-1 and mediate Fc-mediated effector killing of infected cells
J. Richard, D. Nguyen, W. D. Tolbert…·M. Pazgier
This paper designs Ab-CD4 chimeric proteins that open HIV-1 Env trimers to expose non-neutralizing epitopes, enabling both neutralization and ADCC against HIV-1.
DOI 10.1128/mbio.01405-21