Identification of Fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration
M. Ambati, I. Apicella, S. Narendran, S.-b. Wang, H. Leung, F. Pereira, A. Varshney, M. Shadmehr, C. Stains, B. Werner, K. Baker, K. Marion, S. Sadda, E. Taylor, J. Magagnoli, , B. Gelfand
This paper identifies fluoxetine as a potential repurposed drug for dry AMD by showing it inhibits NLRP3-ASC inflammasome activation and reduces RPE degeneration in mice, supported by epidemiological data.
bioRxiv · Jan 11, 2021Immunology