ImmunologybioRxiv
Identification of Fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration
M. Ambati, I. Apicella, S. Narendran…·B. Gelfand
This paper identifies fluoxetine as a potential repurposed drug for dry AMD by showing it inhibits NLRP3-ASC inflammasome activation and reduces RPE degeneration in mice, supported by epidemiological data.
DOI 10.1073/pnas.2102975118