Systems BiologybioRxivPreprint
Opto-MDMi: a dual-lock optogenetic system for robust activation of endogenous p53
Tatsuki Tsuruoka, Takashi Sumikama, Sachiya Nakashima…·Kazuhiro Aoki
This paper introduces Opto-MDMi, a dual-lock optogenetic system that activates endogenous p53 with light, while suppressing basal activity in the dark.
DOI 10.64898/2026.04.13.718310