Yuhei Goto

This paper introduces Opto-MDMi, a dual-lock optogenetic system that activates endogenous p53 with light, while suppressing basal activity in the dark.

This study identifies a novel feedback system regulating Cdk function through Spo12, a small disordered protein that inhibits PP2A, and shows its role in enhancing cell proliferation in fission yeast.

This study measures cyclin-CDK dissociation constants in living cells using FCCS with optimized fluorescent proteins, revealing insights into cyclin-CDK binding redundancy.

This study develops Opto-p53, a light-controllable p53 signaling tool, to regulate p53-dependent cell fate by inducing transcriptional activation, cell death, and cell cycle arrest.

The paper uses a topology-based theory to predict and validate independent control of G2-M and G1-S checkpoints in fission yeast cell cycle by analyzing CDK-cyclin complex dynamics.

This paper develops a biosensor to visualize and manipulate PKA activity in fission yeast, revealing its dynamics during cell cycle phases.

This study applies the SLIPT system to fission yeast to perturb cell cycle-related proteins with improved temporal resolution.

The paper improves a PCB synthesis system for a PhyB-PIF optogenetic tool, enabling stable expression and light-inducible dimerization in cells.