Author

Saketh P. Challa

Broad Institute

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Physiology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

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Aarti H. AsnaniiD· 1 shared Alexandra KuznetsoviD· 1 shared Amanda L. SmythersiD· 1 shared Anthony RosenzweigiD· 1 shared Ariana Vargas‐CastilloiD· 1 shared Bruce M. SpiegelmaniD· 1 shared Casie CurtiniD· 1 shared Chunyan WangiD· 1 shared

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Aarti H. AsnaniORCID

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1 paper

Recent·Most cited

PhysiologyNature Cardiovascular ResearchPeer-reviewedSep 24, 2025

Cardiomyocyte PGC-1α enables physiological adaptations to endurance exercise through suppression of GDF15 and cardiac atrophy

Sumeet A. Khetarpal, Haobo Li, Tevis Vitale…·Anthony Rosenzweig

This study shows that cardiomyocyte PGC-1α is essential for cardiac adaptation to endurance exercise by suppressing GDF15 and preventing cardiac atrophy in mice.

8 citationstop 5%

mousebulk RNA-seq

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