Bruce M. Spiegelman

This study shows that increasing circulating irisin through gene delivery protects mice from stress-induced social withdrawal without exercise.

This study shows that cardiomyocyte PGC-1α is essential for cardiac adaptation to endurance exercise by suppressing GDF15 and preventing cardiac atrophy in mice.

This study identifies MPST as the direct target of EGT, showing it enhances mitochondrial respiration and exercise performance in mice.

This study identifies UCP4b as a cold-inducible gene in Drosophila that protects against cold and obesity, regulated by calcium signaling and counteracted by BMP signaling via MAD.