NeuroscienceJournal of NeurosciencePeer-reviewed
Cocaine-dependent acquisition of locomotor sensitization and conditioned place preference requires D1 dopaminergic signaling through a cyclic AMP, NCS-Rapgef2, ERK and Egr-1/Zif268 pathway
Sunny Zhihong Jiang, Sean C. Sweat, Sam P. Dahlke…·Lee E. Eiden
This study identifies a novel cAMP-NCS-Rapgef2-ERK-Egr-1/Zif268 pathway in D1 dopamine receptor neurons of the nucleus accumbens that is essential for cocaine-induced locomotor sensitization and conditioned place preference.
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