Molecular BiologyNucleic Acids ResearchPeer-reviewed
Rapid degradation of Histone Deacetylase 1 (HDAC1) reveals essential roles in both gene repression and active transcription
David M English, Samuel N Lee, Khadija A Sabat…·Shaun M. Cowley
This study rapidly degrades HDAC1 in ESCs to show its dual role in gene repression and active transcription by modulating histone acetylation at promoters and enhancers.