Cancer BiologybioRxivPreprint
An Endocytic Checkpoint Controls Macrophage PD-1 Function and Immunotherapy Fate
Madhubanti Mullick, Ella McLaren, Suchismita Roy…·Pradipta Ghosh
This paper identifies GIV as a macrophage-intrinsic factor that controls PD1 endocytosis, determining durable response versus hyperprogressive disease to PD1 blockade.