Paired CRISPR screens identify mitochondrial metabolism and UBE2H as aneuploid-specific dependencies in human cancer cell lines
Klaske M. Schukken, Saron M. Akalu, Charles Zou…·Jason M. Sheltzer
Author
Yale University
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
Klaske M. Schukken, Saron M. Akalu, Charles Zou…·Jason M. Sheltzer
Kaitlin Long, Debanjan Bhattacharjee, Samuel H. Newman-Stonebraker…·Jason M. Sheltzer
This study reveals that PAC-1, a clinical-stage oncology compound, targets drug-resistant cancers by disrupting iron homeostasis and exploiting MDR1 expression to induce iron depletion.
Linda Julian, Lisa Crozier, Devon A. Lukow…·Jason M. Sheltzer
This study shows CDK11 is critical for cancer cell survival and identifies 1p36 deletions as a biomarker for CDK11 inhibitor sensitivity, but on-target toxicity limits therapeutic efficacy.
Bhavya Dhaka, Marc Zimmerli, Daniel Hanhart…·Rory Johnson
The paper introduces TransCistor, a framework to identify cis-regulatory lncRNAs with controlled false discovery rates, finding that only a minority of lncRNAs are cis-acting, primarily as activators.