MicrobiologybioRxivPreprint
Delineating the functional role of the PPE50 (Rv3135) - PPE51 (Rv3136) gene cluster in the pathophysiology of Mycobacterium tuberculosis
Ravi Prasad Mukku, Kokavalla Poornima, Sangya Yadav, Tirumalai R. Raghunand
This study identifies the PPE50-PPE51 gene cluster in M. tuberculosis as promoting bacillary persistence through TLR1-dependent immunomodulation, reducing intracellular viability and increasing anti-inflammatory cytokine levels.
DOI 10.1101/2023.03.30.534876