Tirumalai R. Raghunand

This study shows that optineurin deficiency impairs macrophage responses to mycobacterial infection by affecting autophagy and inflammatory cytokine production.

This study identifies the PPE25-PE18-PPE26 gene cluster in Mycobacterium tuberculosis as involved in immune evasion by modulating cytokine levels and macrophage responses.

This study investigates the role of Ca2+ in Mycobacterium tuberculosis DesA1 function, showing that Ca2+ binding stabilizes the protein and is essential for its activity and resistance to isoniazid.

This study identifies the PPE50-PPE51 gene cluster in M. tuberculosis as promoting bacillary persistence through TLR1-dependent immunomodulation, reducing intracellular viability and increasing anti-inflammatory cytokine levels.