BiophysicsbioRxiv
Lipids with negative spontaneous curvature decrease the solubility of the cancer drug paclitaxel in liposomes
Victoria Steffes, Scott MacDonald, John Crowe…·Cyrus R. Safinya
This study shows that lipids with negative spontaneous curvature, like DOPE and GMO, reduce paclitaxel solubility in liposomes, making them unsuitable for drug delivery.
DOI 10.1140/epje/s10189-023-00388-2