17 β-estradiol impedes aortic root dilation and rupture in male Marfan mice
Louis Saddic, Sean S. Escopete, Lior Zilberberg…·Sarah J. Parker
This study shows that 17 β-estradiol reduces aortic root dilation and improves survival in Marfan male mice by inhibiting TNF-NF-κB signaling and preventing aortic smooth muscle cell inflammation.