Self-amplifying mRNA expression is governed by mitochondrial machinery and ACSL4
Lara F. Tshering, Chong Wang, Qing Xiang…·Azadeh Paksa
The paper identifies mitochondrial function and ACSL4 as key regulators of self-amplifying mRNA (saRNA) expression, showing that modulating ACSL4 improves saRNA expression across cell types.