Cancer BiologyAdvanced SciencePeer-reviewed
The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment Through Regulation of NUMB Levels
Simone Sabbioni, Maria Grazia Filippone, Letizia Amadori…·Daniela Tosoni
The paper identifies the CRL7FBXW8 complex as an E3 ligase responsible for NUMB hyper-degradation in breast cancer, showing its inhibition rescues transformation phenotypes.
3 citations