Cancer BiologybioRxivPreprint
Spatial patterns of APOBEC mutagenesis in the tumour microenvironment of Asian breast cancer
Zi-Ching Tan, Yang Wu, Zhen Wei Neo…·Jia Wern Pan
This study investigates how APOBEC mutagenesis and A3B deletion affect immune activation in Asian breast cancer using spatial transcriptomics, finding that mitochondrial mutations and cGAS-STING pathway activation drive immune responses instead of neoantigens.
DOI 10.64898/2026.01.01.697328