Molecular BiologybioRxivPreprint
Embryological cellular origins and hypoxia-mediated mechanisms in PIK3CA-Driven refractory vascular malformations
Sota Torii, Keiki Nagaharu, Nanako Nakanishi…·Kazuaki Maruyama
This study identifies embryonic origins and hypoxia-driven mechanisms in PIK3CA-driven vascular malformations, showing that HIF-1 and VEGF-A inhibition reduces abnormalities.