Cancer BiologyJournal of Cancer Science and Clinical TherapeuticsPeer-reviewed
Pharmacodynamic evaluation of AUM001/tinodasertib, an oral inhibitor of mitogen-activated protein kinase (MAPK)-interacting protein kinase 1, 2 (MNK1/2) in preclinical models and tissues from a Phase 1 clinical study
Bong Hwa Gan, Lay Hoon Lee, Reika Takeda…·Veronica Novotny-Diermayr
This paper evaluates the pharmacodynamic effects of AUM001/tinodasertib in preclinical models and human tissues from a Phase 1 study, showing dose-dependent inhibition of eIF4E phosphorylation in tumors and PBMCs.