Microbiota-specific serum IgG links gut and joints through immune-endothelial crosstalk in arthritis
Eva Schmid, Nadine Otterbein, Stephen Ariyeloye…·Mario M. Zaiss
This study identifies microbiota-specific serum IgG as a mediator of gut-joint immune-endothelial crosstalk in arthritis, showing its role in initiating autoimmunity through endothelial barrier impairment and microbial translocation.