Cell BiologyNature CommunicationsPeer-reviewed
Bnip3lb-driven mitophagy sustains expansion of the embryonic hematopoietic stem cell pool
Eleanor Meader, Morgan T. Walcheck, Mindy Leder…·Trista E. North
This study shows that Bnip3lb-driven mitophagy maintains embryonic HSPC multipotency and expansion by regulating ROS levels, and enhances ex vivo hematopoietic potential of iPSC-derived HSPCs.