J. Baum

A fast-killing tyrosine amide ((S)-SW228703) with blood and liver-stage antimalarial activity associated with the Cyclic Amine Resistance Locus (PfCARL)

This paper identifies (S)-SW228703, a tyrosine amide with fast-killing antimalarial activity against blood and liver stages of Plasmodium falciparum, and links resistance to mutations in PfCARL and PfACT.

4D live-cell imaging of microgametogenesis in the human malaria parasite Plasmodium falciparum

This study uses 4D live-cell imaging to analyze microgametogenesis in Plasmodium falciparum, revealing proteasomal activity's critical role in DNA replication and axoneme formation.

Plasmodium falciparum protein Pfs16 is a target for transmission-blocking antimalarial drug development

This study identifies Pfs16 as the cellular target of the N-4HCS compound DDD01035881, which blocks Plasmodium male gamete formation.

Tannic Acid Inhibits α-Synuclein Amyloid Fibril Formation via Binding to the Monomer N-terminal Domain

This study shows tannic acid inhibits α-synuclein fibril formation by binding to its N-terminal domain, with pH dependence observed through NMR, AFM, and ThT assays.

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

This paper characterizes MMV693183, a novel antimalarial compound targeting acetyl-CoA synthetase, showing in vitro and in vivo efficacy against Plasmodium species and transmission blocking.

Blunted Fas signaling favors RIPK1-driven neutrophil necroptosis in critically ill COVID-19 patients

The paper shows that in critically ill COVID-19 patients, dysregulated Fas signaling leads to increased RIPK1-driven necroptosis in neutrophils, contributing to disease severity.

DHA but not EPA induces the trans-differentiation of C2C12 cells into white-like adipocytes phenotype

This study investigates the effects of EPA and DHA on C2C12 cell differentiation, finding that DHA induces a white-like adipocyte phenotype while EPA does not.

Prioritization of antimicrobial targets by CRISPR-based oligo recombineering

This paper introduces CORe, a CRISPR-based method to prioritize reactive amino acids for drug discovery by linking sequence reactivity to protein function in Toxoplasma gondii.

Molecular Dynamics Analysis of a Flexible Loop at the Binding Interface of the SARS-CoV-2 Spike Protein Receptor-Binding Domain

This paper uses molecular dynamics simulations to analyze the conformational flexibility of the SARS-CoV-2 RBD Loop 3 and identifies new unbound substates that could be therapeutic targets.

Actomyosin forces and the energetics of red blood cell invasion by the malaria parasite Plasmodium falciparum

This study investigates the role of actomyosin motors in Plasmodium falciparum invasion of red blood cells, identifying three energetic barriers and distinct myosin functions.

NMR unveils an N-terminal interaction interface on acetylated-α-synuclein monomers for recruitment to fibrils

This paper identifies an N-terminal binding interface on acetylated-α-synuclein monomers that interacts with fibrils and off-pathway oligomers, revealing a mechanism for fibril elongation and potential therapeutic targets.

Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis

The paper presents the full-length structure of Plasmodium falciparum Myosin A (PfMyoA) and its light chain PfELC, revealing interactions critical for motor function and identifying PfELC as a potential antimalarial target.

Dissection-independent production of a protective whole-sporozoite malaria vaccine

A four-step process isolates pure malaria sporozoites from mosquitoes without manual dissection, enabling a whole-parasite vaccine that provides sterilizing protection.

Identification and characterisation of a phospholipid scramblase in the malaria parasite Plasmodium falciparum

The paper identifies and characterizes a phospholipid scramblase in Plasmodium falciparum, showing its activity and expression but not essentiality for erythrocyte invasion.

Probing the effect of glycosaminoglycan depletion on integrin interactions with collagen I fibrils in the native ECM environment.

This study investigates how glycosaminoglycan depletion affects integrin 2I domain interactions with collagen I fibrils and their mechanical properties in the ECM.

Artemisinin-resistant malaria parasites show enhanced transmission to mosquitoes under drug pressure

Artemisinin-resistant malaria parasites show reduced sensitivity to transmission-blocking effects of artemisinin drugs, increasing their transmission to mosquitoes under drug pressure.

A machine learning approach to define antimalarial drug action from heterogeneous cell-based screens

The paper develops a semi-supervised machine learning method to classify drug-induced morphological changes in malaria parasite cultures, enabling clustering of drugs by mechanism of action.

Single-molecule nanopore sensing of actin dynamics and drug binding

This study uses nanopore sensing to analyze actin dynamics and drug binding in native, unmodified actin molecules, revealing transitional states and binding stoichiometries.

Collagen I weakly interacts with the β-sheets of β2-microglobulin and enhances conformational exchange to induce amyloid formation

This study shows collagen I weakly interacts with β2-microglobulin, promoting conformational exchange that leads to amyloid formation.

Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion

This study shows that F-actin is essential for nuclear passage during host cell invasion by apicomplexan parasites, stabilizing the junction and facilitating nuclear movement.

Quantitative and rapid Plasmodium falciparum malaria diagnosis and artemisinin-resistance detection using a CMOS Lab-on-Chip platform

This paper develops a CMOS Lab-on-Chip platform for quantitative Plasmodium falciparum detection and artemisinin-resistance identification using non-optical DNA sensing.

The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection

This study investigates how cholesterol levels in red blood cells affect malaria parasite invasion, finding no significant impact from serum cholesterol but suggesting genetic variations in membrane lipid composition may influence susceptibility.

Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity

This study shows that β-synuclein reduces the cytotoxicity and seeding capacity of α-synuclein fibrils by increasing their dynamics without altering their core structure.

Stable knockout and complementation of receptor expression using in vitro cell line derived reticulocytes for dissection of host malaria invasion requirements

This study uses reticulocytes from an immortalized erythroblast cell line to investigate host receptor roles in malaria invasion, showing basigin's essential function and cyclophilin B's non-requirement.