PhysiologybioRxiv
Inhibition of the sodium-dependent HCO3 -transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype.
V. Saint-Criq, A. Guequen, A. R. Philp…·C. A. Flores
This study shows that inhibiting SLC4A4, a sodium-dependent bicarbonate cotransporter, in airway epithelial cells causes a CF-like phenotype with mucus accumulation and reduced mucociliary clearance.