Cancer BiologybioRxiv
CXCR4 allows T cell acute lymphoblastic leukemia to escape from JAK1/2 and BCL2 inhibition through CNS infiltration
K. L. Walker, S. P. Rinella, N. J. Hess…·C. M. Capitini
This study shows that combining JAK1/2 and BCL2 inhibitors in T-ALL leads to CNS infiltration, which is reduced by adding a CXCR4 inhibitor.
DOI 10.1080/10428194.2021.1910684