Increased spontaneous Ca2+ activity in Cardiac Purkinje cells after myocardial infarction; A consequence of a dramatic shift of SERCA isoforms as potential adaptation to acute ischemia?
B. D. Stuyvers, P. A. Boyden, R. Amin, L. L. Wiede, J. Dore, H. E. ter Keurs, W. Dun, Y. Guo, M. Haissaguerre, M. Hocini, F. Brette, O. Bernus, S. Chaigne, V. Loyer, J. Naulin, , T. Benoukraf
This study shows that increased spontaneous Ca2+ activity in cardiac Purkinje cells after myocardial infarction is due to a shift in SERCA2 isoforms, specifically increased SERCA2b and reduced SERCA2a.
bioRxiv · Oct 23, 2023 · PreprintCell Biology