Author

D. Tenen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

B. Spiegelman· 2 shared C. Jacobs· 2 shared E. D. Rosen· 2 shared A. Banks· 1 shared A. Courcoulas· 1 shared A. De Vincenzo· 1 shared A. Giordano· 1 shared A. Gulko· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCell Biology

B. Spiegelman

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Author profile →

5 papers

Recent·Most cited

A single cell atlas of human and mouse white adipose tissue

M. P. Emont, C. Jacobs, A. L. Essene, D. Pant, D. Tenen, G. Colleluori, A. De Vincenzo, A. M. Jorgensen, H. Dashti, A. Stefek, E. McGonagle, S. Strobel, S. Laber, S. Agrawal, G. P. Westcott, , E. D. Rosen

This study creates single-cell atlases of human and mouse white adipose tissue, identifying cell types and their roles in metabolic disease across different body weights and diets.

bioRxiv · Nov 9, 2021Physiology

C/EBPα acts as an RNA binding protein essential for its chromatin recruitment and promotes Macrophage differentiation

Y. Zhang, M. Bassal, D. Friedrich, S. Ummarino, T. Verbiest, J. Zhang, D. Tenen, A. Haribabu, D. G. Tenen

The paper shows C/EBPα binds RNA via novel domains, recruits to enhancer sites, and promotes Macrophage differentiation by regulating PU.1 expression.

bioRxiv · Oct 20, 2021 · PreprintCell Biology

Three-dimensional Genome Organization Maps in Normal Haematopoietic Stem Cells and Acute Myeloid Leukemia

B. Wang, L. Kong, D. Babu, R. Choudhary, W. Fam, J. Q. Tng, Y. Goh, B. Wong Jern Han, X. Liu, F. F. Song, P. Chia, M. C. Chan, O. An, C. Y. Tham, T. Benoukraf, , M. J. Fullwood

This study maps 3D genome organization in normal and AML haematopoietic stem cells, finding increased chromatin loops to oncogenes in AML and identifying MEIS1 and HOXA9 as key oncogenes regulated by these interactions.

bioRxiv · Apr 18, 2020 · PreprintCancer Biology

Obesity-linked PPARγ S273 phosphorylation promotes insulin resistance through Growth Differentiation Factor 3

J. A. Hall, D. Ramachandran, H. C. Roh, J. R. DiSpirito, T. Belchior de Oliveira, P.-J. H. Zushin, C. J. Palmer, S. Hong, A. I. Mina, B. Liu, Z. Deng, P. Aryal, C. Jacobs, D. Tenen, C. W. Brown, , A. Banks

This study shows that preventing PPARγ S273 phosphorylation reduces insulin resistance without weight gain or side effects, identifying Gdf3 as a key mediator.

bioRxiv · Jan 13, 2020Cell Biology

Thermoneutrality induces skeletal muscle myopathy via brown adipose tissue in an IRF4- and myostatin-dependent manner

X. Kong, P. Zhou, T. Yao, L. Kazak, D. Tenen, A. Lyubetskaya, B. Dawes, L. Tsai, B. Kahn, B. Spiegelman, T. Liu, E. D. Rosen

This study shows that thermoneutrality causes skeletal muscle myopathy through brown adipose tissue via IRF4 and myostatin mechanisms.

bioRxiv · Mar 2, 2018Physiology