D. Babu

Inhibition of BCR::ABL1 tyrosine kinase activity Aids in the Generation of Stable Chronic Myeloid Leukemia Induced Pluripotent Stem Cells

This study generates stable CML-iPSCs by inhibiting BCR::ABL1 tyrosine kinase activity, enabling disease modeling and drug screening.

SYS-Mut: Decoding the Functional Significance of Rare Somatic Mutations in Cancer

SYS-Mut identifies functional significance of rare somatic mutations in cancer by integrating multi-omic data, revealing lipidogenic networks as therapeutic targets in HNSC.

The EphB2-MYC Axis is a Major Determinant of Barrett's Pathobiology and a Therapeutic Vulnerability in Esophageal Cancer

This study identifies the EphB2-MYC axis as a key driver of Barrett's Esophagus progression to esophageal adenocarcinoma and a potential therapeutic target.

Three-dimensional Genome Organization Maps in Normal Haematopoietic Stem Cells and Acute Myeloid Leukemia

This study maps 3D genome organization in normal and AML haematopoietic stem cells, finding increased chromatin loops to oncogenes in AML and identifying MEIS1 and HOXA9 as key oncogenes regulated by these interactions.

Cooperation only for high rewards - a solvable task-based study on free-ranging dogs

This study investigates cooperation and social tolerance in free-ranging dogs through three tasks with varying food rewards, finding context-dependent cooperation and food sharing.