T. Borghuis

Three dimensional fibrotic extracellular matrix directs microenvironment fiber remodeling by fibroblasts

This study shows that 3D fibrotic ECM hydrogels alter fibroblast fiber organization and mechanical properties, promoting pro-fibrotic responses.

IL-11 disrupts alveolar epithelial progenitor function

This study investigates how IL-11 affects alveolar epithelial progenitor function in IPF, finding it disrupts regeneration and suppresses mature cell formation.

Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts

This study shows that fibrotic stiffness activates fibrotic genes and senescence-associated secretory factors in lung fibroblasts, potentially driving disease progression in IPF.

An in vitro model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing composition

This study creates an in vitro fibrosis model using crosslinked native ECM hydrogels to alter biomechanics without changing composition, showing increased stiffness and fibroblast myofibroblastic differentiation.

Osteoprotegerin is elevated in pulmonary fibrosis and associates with IPF progression

This study shows OPG levels are elevated in fibrotic lung tissue and correlate with IPF disease progression and reduced lung function.