Secreted antigen A peptidoglycan hydrolase is essential for Enterococcus faecium cell separation and priming of immune checkpoint inhibitor cancer therapy
S. Klupt, K. T. Fam, X. Zhang, P. K. Chodisetti, A. Mehmood, T. Boyd, D. Grotjahn, D. Park, H. C. Hang
This study identifies SagA as essential for E. faecium growth, cell separation, and immune checkpoint inhibitor cancer therapy, showing its role in muropeptide production and NOD2 activation.
bioRxiv · Nov 19, 2023Microbiology