Author

T. Dwight

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

A. B. Moreno-Cardenas· 1 shared A. Buffet· 1 shared A. M. Martinez-Montes· 1 shared A. Oleaga Alday· 1 shared A. Petrin· 1 shared B. Calsina· 1 shared B. Chamberlain· 1 shared B. K. Allen· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. B. Moreno-Cardenas

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Author profile →

2 papers

Recent·Most cited

Convergent genetic adaptation in human tumors developed under systemic hypoxia and in populations living at high altitudes

C. Arenillas, J. Ruiz-Cantador, L. Celada, B. Calsina, E. Garcia-Galea, D. Datta, R. Fasani, A. B. Moreno-Cardenas, J. J. Alba-Linares, B. Miranda, A. M. Martinez-Montes, C. Alvarez Escola, B. Lecumberri, E. A. Gonzalez Garcia, S. K. Flores, , Rueda

This study links EPAS1HIF2 genetic adaptations in high-altitude populations to similar mutations in hypoxia-driven tumors, showing shared mechanisms in hypoxia response and tumorigenesis.

bioRxiv · Jun 10, 2024Cancer Biology

Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligence

B. K. Allen, M. M. Kulkarni, B. Chamberlain, T. Dwight, C. Koh, R. Samant, F. Jernigan, J. Rice, D. Tan, S. Li, K. Marino, H. Huang, E. Chiswick, B. Tesar, S. Sparks, , W. Sherman

This paper designs a small molecule STING agonist, SNX281, using computational methods and AI, showing systemic activity and antitumor effects in mice.

bioRxiv · May 23, 2022 · PreprintCancer Biology