Cell BiologybioRxiv
A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation
T. E. Knudsen, W. Hamilton, M. Proks…·J. M. Brickman
This study shows ESRRB supports pluripotency when NANOG is present but promotes a primitive endoderm identity when NANOG is absent, with their stoichiometry influencing differentiation.
DOI 10.1016/j.cels.2023.07.008