Proton export drives the Warburg Effect
S. Russell, L. Xu, Y. Kam, D. Abrahams, B. Ordway, A. Lopez, M. M. Bui, J. Johnson, T. Epstein, E. Ruiz, M. Lloyd, P. Swietach, D. Verduzco, J. Wojtkowiak, R. Gillies
This study shows that proton export drives the Warburg Effect by increasing intracellular alkalization, enhancing glycolytic flux, and promoting cancer aggressiveness.
bioRxiv · Sep 20, 2021 · PreprintCancer Biology