Author

D. Abrahams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Ibrahim-Hashim· 2 shared B. Ordway· 2 shared P. Swietach· 2 shared R. Gillies· 2 shared S. Russell· 2 shared A. A. Ojeda· 1 shared A. El-Kenawi· 1 shared A. Lopez· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

A. Ibrahim-Hashim

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Author profile →

3 papers

Recent·Most cited

L-DOS47 enhances response to immunotherapy in pancreatic cancer tumor

B. V. Jardim-Perassi, P. Irrera, D. Abrahams, V. C. Estrella, B. Ordway, S. R. Byrne, A. A. Ojeda, C. J. Whelan, J. Kim, M. S. Beatty, S. Damgaci-Erturk, D. L. Longo, K. J. Gaspar, G. M. Siegers, B. A. Centeno, , A. Ibrahim-Hashim

This study shows that L-DOS47, a urease immunoconjugate, enhances anti-PD1 immunotherapy efficacy in pancreatic cancer by neutralizing tumor acidity.

bioRxiv · Aug 28, 2023 · PreprintCancer Biology

Proton export drives the Warburg Effect

S. Russell, L. Xu, Y. Kam, D. Abrahams, B. Ordway, A. Lopez, M. M. Bui, J. Johnson, T. Epstein, E. Ruiz, M. Lloyd, P. Swietach, D. Verduzco, J. Wojtkowiak, R. Gillies

This study shows that proton export drives the Warburg Effect by increasing intracellular alkalization, enhancing glycolytic flux, and promoting cancer aggressiveness.

bioRxiv · Sep 20, 2021 · PreprintCancer Biology

Lymph Nodes Inhibit T-cell Effector Functions Locally by Establishing Acidic Niches

H. Wu, V. Estrella, P. Enriquez-Navas, A. El-Kenawi, S. Russell, D. Abrahams, A. Ibrahim-Hashim, D. Longo, Y. Reshetnyak, K. Luddy, M. Damaghi, S. R. Pillai, M. Beatty, S. Pilon-Thomas, P. Swietach, r. gillies

The paper shows that acidic niches in lymph nodes inhibit T-cell effector functions by blocking lactic acid efflux and reducing glycolysis, keeping T-cells in a state of stasis.

bioRxiv · Jul 2, 2019 · PreprintPhysiology