Paracrine enhancement of tumor cell proliferation provides indirect stroma-mediated chemoresistance via acceleration of tumor recovery between chemotherapy cycles.
D. Miroshnychenko, T. Miti, P. Kumar, A. K. Miller, M. Laurie, N. Giraldo, M. M. Bui, P. M. Altrock, D. Basanta, A. Marusyk
The paper investigates how stromal factors indirectly enhance tumor chemoresistance by accelerating tumor recovery between chemotherapy cycles through paracrine signaling.
bioRxiv · Feb 7, 2023 · PreprintCancer Biology