Proton export drives the Warburg Effect
S. Russell, L. Xu, Y. Kam…·R. Gillies
This study shows that proton export drives the Warburg Effect by increasing intracellular alkalization, enhancing glycolytic flux, and promoting cancer aggressiveness.
Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
S. Russell, L. Xu, Y. Kam…·R. Gillies
This study shows that proton export drives the Warburg Effect by increasing intracellular alkalization, enhancing glycolytic flux, and promoting cancer aggressiveness.
H. Wu, V. Estrella, P. Enriquez-Navas…·r. gillies
The paper shows that acidic niches in lymph nodes inhibit T-cell effector functions by blocking lactic acid efflux and reducing glycolysis, keeping T-cells in a state of stasis.
A. El-Kenawi, C. Gatenbee, M. Robertson-Tessi…·R. Gillies
This study shows that tumor acidity promotes prostate cancer by altering macrophage phenotype, both in vitro and in vivo, and is supported by in silico modeling.