A. Lopez

Stromal and Endothelial Transcriptional Changes during progression from MGUS to Myeloma and after Treatment Response

This study identifies transcriptional changes in stromal and endothelial cells during MGUS to myeloma progression and treatment response, revealing a tumor-permissive BME signature that is modulated by therapy.

Environmental DNA as a complementary tool for biodiversity monitoring: A multi-technique and multi-trophic approach to investigate cetacean distribution and feeding ecology

This study uses environmental DNA to characterize cetacean communities and their prey in coastal waters, finding similar results to visual surveys and identifying year-round presence.

Electroadhesive hydrogel interface for prolonged mucosal theranostics

This paper develops e-GLUE, an electroadhesive hydrogel interface that enables prolonged mucosal retention and demonstrates its utility in GI theranostics.

In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1-mutant lung cancer

The paper identifies CD38 as a therapeutic target in LKB1-mutant lung cancer through in vivo metabolomics and shows that targeting CD38 inhibits tumor growth.

MeC3HDZ1/MeCNA is a strong candidate for cassava storage root productivity improvement.

The paper identifies MeC3HDZ1 as a key transcription factor in cassava storage root development and shows it regulates genes involved in xylem differentiation.

Rapid estimation of cortical neuron activation thresholds by transcranial magnetic stimulation using convolutional neural networks

This paper develops 3D CNNs to rapidly estimate TMS activation thresholds for cortical neurons using local E-field data, achieving high accuracy and computational efficiency.

Proton export drives the Warburg Effect

This study shows that proton export drives the Warburg Effect by increasing intracellular alkalization, enhancing glycolytic flux, and promoting cancer aggressiveness.

Utilizing Digital Pathology to Quantify Stromal Caveolin-1 Expression in Malignant and Benign Ovarian Tumors: Associations with Clinicopathological Parameters and Clinical Outcomes

This study quantifies stromal caveolin-1 expression in ovarian tumors using IHC and IF, finding downregulation in cancer stroma but no correlation with clinical outcomes.

Identification of QTL hotspots affecting agronomic traits and high-throughput vegetation indices in rainfed wheat

This study identifies QTL hotspots associated with agronomic traits and vegetation indices in rainfed wheat using GWAS and candidate gene analysis.

HIV Vpr modulates the host DNA damage response at two independent steps to damage DNA and repress double-strand DNA break repair

This study shows HIV Vpr modulates the host DNA damage response by inducing DNA damage and repressing double-strand break repair through two independent mechanisms.

APEX2 proximity proteomics resolves flagellum subdomains and identifies flagellum tip-specific proteins in Trypanosoma brucei

This paper uses APEX2 proximity proteomics to identify flagellum subdomain-specific proteins in Trypanosoma brucei, revealing tip-specific proteins involved in signal transduction.

CpG-creating Mutations are Costly in Many Human Viruses

The paper examines the cost of CpG-creating mutations in various human viruses using existing genomic data and finds they are generally costly.

Complementing 16S rRNA gene amplicon sequencing with estimates of total bacterial load to infer absolute species concentrations in the vaginal microbiome

The paper combines 16S rRNA gene amplicon sequencing with total bacterial load estimates to infer absolute species concentrations in the vaginal microbiome, showing good correlation with targeted qPCR for relative abundances above 10%.

The most abundant cyst wall proteins of Acanthamoeba castellanii are three sets of lectins that bind cellulose and chitin and localize to distinct structures in cyst walls

This paper identifies three lectin families as the most abundant cyst wall proteins in A. castellanii, showing their distinct localization and carbohydrate-binding properties.

Illuminating women’s hidden contribution to the foundation of theoretical population genetics

The paper identifies women programmers (APs) in early computational population genetics, finding 43% of APs were women, significantly higher than the 7% of authors, highlighting their unrecognized contributions.