Optineurin provides a mitophagy contact site for TBK1 activation
K. Yamano, M. Sawada, R. Kikuchi…·N. Matsuda
This study identifies OPTN as a platform for TBK1 activation during mitophagy, showing OPTN facilitates TBK1 assembly at mitochondrial-autophagosome contact sites and enhances its activation through hetero-autophosphorylation.