M. Hirasaki

This study compares gene expression in postmitotic cardiac myocytes and proliferative non-cardiomyocytes from young and aged mice, identifying age-related changes in mitochondrial genes and snoRNAs.

The paper identifies two single-nucleotide variants in the PTEN-induced kinase 1 gene associated with lower recurrence rates in colorectal cancer patients undergoing adjuvant chemotherapy.

The paper shows that inhibiting mitochondrial respiration with antimycin A reduces stress-induced senescence in human fibroblasts by improving proteostasis.

The paper shows that both DNA-binding domains of Mga repress meiosis-related genes in mouse ESCs, with bHLHZ playing a key role in suppressing Meiosin expression.

This study shows that NPC1L1 inhibition reduces chylomicron assembly and secretion in intestinal cells by limiting cholesterol availability, leading to large lipid droplet formation.