Author

T. G. Franklin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

J. N. Pruneda· 3 shared J. V. Nguyen· 2 shared P. P. Geurink· 2 shared A. F. Schubert· 1 shared C. G. Roberts· 1 shared D. J. Sanderson· 1 shared D. Komander· 1 shared G. D. Warren· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

J. N. Pruneda

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3 papers

Recent·Most cited

BiochemistrybioRxivJun 5, 2023

Bacterial mimicry of eukaryotic HECT ubiquitin ligation

T. G. Franklin, P. S. Brzovic, J. N. Pruneda

This study identifies and characterizes bacterial HECT-like E3 ligases, revealing structural insights into their polyUb ligation mechanism and specificity.

DOI 10.1016/j.molcel.2023.11.017

bacteria (other)protein structure

𝕏 PostBluesky

BiochemistrybioRxivMay 11, 2022

Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA

G. D. Warren, T. Kitao, T. G. Franklin…·J. N. Pruneda

This study identifies and characterizes the deubiquitinase domain of LotA from L. pneumophila that specifically targets K6-linked poly-ubiquitin during infection.

DOI 10.1016/j.molcel.2022.11.022

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

BiochemistrybioRxivMar 28, 2020

Identification and characterization of diverse OTU deubiquitinases in bacteria

A. F. Schubert, J. V. Nguyen, T. G. Franklin…·D. Komander

The paper identifies and characterizes OTU deubiquitinases in bacteria, showing their structural and functional similarities to human and viral OTUs.

DOI 10.15252/embj.2020105127

bacteria (other)experimental assay

𝕏 PostBluesky