MicrobiologybioRxiv
Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity
C. D. Heer, D. J. Sanderson, L. S. Voth…·C. Brenner
This study shows that SARS-CoV-2 infection upregulates MARylating PARPs and NAD synthesis enzymes, and that enhancing NAD levels can reduce viral replication.
DOI 10.1074/jbc.ra120.015138