Author

T. Graf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Evolutionary Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. C. D. Paixao· 2 shared E. Delatorre· 2 shared F. C. Motta· 2 shared G. Bello· 2 shared L. Appolinario· 2 shared M. M. Siqueira· 2 shared P. C. Resende· 2 shared S. B. Fernandes· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMicrobiology

A. C. D. Paixao

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Author profile →

5 papers

Recent·Most cited

Carm1 regulates the speed of C/EBPa-induced transdifferentiation by a cofactor stealing mechanism

G. T. Garcia, E. Kowenz-Leutz, T. V. Tian, A. Klonizakis, J. Lerner, L. De Andres-Aguayo, C. Berenguer, M. P. Carmona, M. V. Casadesus, R. Bulteau, M. Francesconi, S. Peiro, K. S. Zaret, A. Leutz, T. Graf

This study shows that a C/EBP mutation accelerates B cell to macrophage transdifferentiation by altering PU.1 interactions, and that Carm1 methylation regulates this process.

bioRxiv · Oct 3, 2022Cell Biology

The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylatedIgG1 in naive but not antigen-experienced vaccinees

J. Van Coillie, T. Pongracz, J. Rahmoeller, H.-J. Chen, C. E. Geyer, L. A. van Vught, J. S. Buhre, T. Sustic, T. L. J. van Osch, M. Steenhuis, W. Hoepel, W. Wang, A. Lixenfeld, J. Nouta, S. Keijzer, , Fatebenefratelli-Sacco Infectious Diseases Physic

The paper examines afucosylated IgG1 responses after BNT162b2 vaccination, finding transient responses in naive individuals that correlate with second-dose antibody levels.

bioRxiv · Feb 14, 2022Immunology

A potential SARS-CoV-2 variant of interest (VOI) harboring mutation E484K in the Spike protein was identified within lineage B.1.1.33 circulating in Brazil

P. C. Resende, T. Graf, A. C. D. Paixao, L. Appolinario, R. S. Lopes, A. C. F. Mendonca, A. S. B. da Rocha, F. C. Motta, L. G. L. Neto, R. Khouri, C. I. de Oliveira, P. Santos-Muccillo, J. F. Bezerra, D. L. F. Teixeira, I. Riediger, , M. M. Siqueira

bioRxiv · Mar 12, 2021Microbiology

Genomic surveillance of SARS-CoV-2 reveals community transmission of a major lineage during the early pandemic phase in Brazil

P. C. Resende, E. Delatorre, T. Graf, D. Mir, F. C. Motta, L. Appolinario, A. C. D. Paixao, M. Ogrzewalska, B. Caetano, M. C. Santos, J. A. Ferreira, E. C. Souza Junior, S. P. Silva, S. B. Fernandes, L. A. Vianna, , M. M. Siqueira

This study analyzes SARS-CoV-2 genetic diversity in Brazil during the early pandemic phase, identifying community transmission of a major lineage and its spread to other countries.

bioRxiv · Jun 17, 2020 · PreprintEvolutionary Biology

RAS mutations drive proliferative chronic myelomonocytic leukemia via activation of a novel KMT2A-PLK1 axis

R. M. Carr, D. Vorobyev, T. Lasho, D. L. Marks, E. J. Tolosa, A. Vedder, L. Almada, A. Yurchenko, I. Padioleau, B. Alver, G. Coltro, M. Binder, S. L. Safgren, I. Horn, X. You, , M. M. Patnaik

This study identifies RAS mutations as drivers of proliferative CMML through a novel KMT2A-PLK1 axis, showing PLK1 inhibition can improve disease outcomes in patient-derived xenografts.

bioRxiv · Dec 23, 2019 · PreprintCancer Biology