T. Gren

Maramycin, a cytotoxic isoquinolinequinone terpenoid produced through heterologous expression of a bifunctional indole prenyltransferase /tryptophan indole-lyase in S. albidoflavus

The paper reports the discovery of maramycin, a novel isoquinolinequinone alkaloid produced through heterologous expression of a bifunctional enzyme in Streptomyces albidoflavus, showing moderate cytotoxicity against prostate cancer cells.

Biosynthesis of the azoxy compound azodyrecin from Streptomyces mirabilis P8-A2

This study identifies and characterizes the biosynthetic pathway for azodyrecin, an azoxy compound produced by Streptomyces mirabilis P8-A2, revealing key enzymes and gene cluster distribution across Streptomyces species.

Identification of the 216kbp gene cluster and structure elucidation of gargantulides B and C, new complex 52-membered macrolides from Amycolatopsis sp.

This study identifies a 216 kbp gene cluster and elucidates the structures of gargantulides B and C, new 52-membered macrolides from Amycolatopsis sp., revealing their biosynthetic pathway and antibacterial activity.

Characterization and Engineering of Streptomyces griseofuscus DSM 40191 as a Potential Host for Heterologous Expression of Biosynthetic Gene Clusters

This paper characterizes Streptomyces griseofuscus DSM 40191 as a potential heterologous host for biosynthetic gene clusters and demonstrates its ability to produce secondary metabolites.

Distribution of Epsilon-Polylysine Synthetases in Coryneform Bacteria Isolated from Cheese and Human Skin

The paper identifies epsilon-polylysine synthetase genes in coryneform bacteria from cheese and human skin, suggesting natural production of epsilon-polylysine in these environments.