T. Weber

Lydicamycins Induce Morphological Differentiation in Actinobacterial Interactions

This study identifies lydicamycins as inducers of morphological differentiation in actinobacterial interactions using co-cultivation and multi-omics approaches.

Expanding the genome information on Bacillales for biosynthetic gene cluster discovery

This study presents 121 new Bacillales genomes, identifies 1,176 biosynthetic gene clusters, and provides open-access data to enhance research on secondary metabolite production.

Alligamycin A, an unprecedented antifungal β-lactone spiroketal macrolide from Streptomyces iranensis

This paper identifies alligamycin A, a novel antifungal compound from Streptomyces iranensis, and demonstrates its potent antifungal activity against clinically relevant fungi.

Maramycin, a cytotoxic isoquinolinequinone terpenoid produced through heterologous expression of a bifunctional indole prenyltransferase /tryptophan indole-lyase in S. albidoflavus

The paper reports the discovery of maramycin, a novel isoquinolinequinone alkaloid produced through heterologous expression of a bifunctional enzyme in Streptomyces albidoflavus, showing moderate cytotoxicity against prostate cancer cells.

A treasure trove of 1,034 actinomycete genomes

The paper provides over 1,000 high-quality Actinomycetia genomes, revealing genomic structures and biosynthetic gene cluster organization with ecological and biotechnological implications.

Biosynthesis of the azoxy compound azodyrecin from Streptomyces mirabilis P8-A2

This study identifies and characterizes the biosynthetic pathway for azodyrecin, an azoxy compound produced by Streptomyces mirabilis P8-A2, revealing key enzymes and gene cluster distribution across Streptomyces species.

Dissecting the impact of somatic hypermutation on SARS-CoV-2 neutralization and viral escape

The paper reverts mutations in SARS-CoV-2 antibodies to study SHM's impact on neutralization, finding that some mutations are critical for neutralizing Omicron variants.

Streptomyces alleviate abiotic stress in plant by producing pteridic acids

This study identifies pteridic acids produced by Streptomyces that alleviate drought and salinity stress in Arabidopsis by promoting root growth and inducing stress response genes.

Proposal and extensive test of a calibration protocol for crop phenology models

This paper proposes and tests a calibration protocol for crop phenology models, reducing prediction error and team variability by 22%.

Bayesian multi-level calibration of a process-based maize phenology model

This paper improves phenology model calibration by using a Bayesian multi-level approach to account for cultivar and ripening group differences in maize, enhancing accuracy and identifying model limitations.

Identification of the 216kbp gene cluster and structure elucidation of gargantulides B and C, new complex 52-membered macrolides from Amycolatopsis sp.

This study identifies a 216 kbp gene cluster and elucidates the structures of gargantulides B and C, new 52-membered macrolides from Amycolatopsis sp., revealing their biosynthetic pathway and antibacterial activity.

Characterization and Engineering of Streptomyces griseofuscus DSM 40191 as a Potential Host for Heterologous Expression of Biosynthetic Gene Clusters

This paper characterizes Streptomyces griseofuscus DSM 40191 as a potential heterologous host for biosynthetic gene clusters and demonstrates its ability to produce secondary metabolites.

CRISPR-nRAGE, a Cas9 nickase-reverse transcriptase assisted versatile genetic engineering toolkit for E. coli

CRISPR-nRAGE enables DSB-free, single-nucleotide resolution genome editing in E. coli by combining Cas9 nickase and reverse transcriptase, allowing substitutions, deletions, and insertions.

Genomic and chemical diversity of Bacillus subtilis secondary metabolites against plant pathogenic fungi

This study examines the genomic and chemical diversity of secondary metabolites in Bacillus subtilis strains to understand their biocontrol properties against plant pathogenic fungi.

Distribution of Epsilon-Polylysine Synthetases in Coryneform Bacteria Isolated from Cheese and Human Skin

The paper identifies epsilon-polylysine synthetase genes in coryneform bacteria from cheese and human skin, suggesting natural production of epsilon-polylysine in these environments.

Longitudinal isolation of potent near-germline SARS-CoV-2-neutralizing antibodies from COVID-19 patients

This study isolates potent SARS-CoV-2-neutralizing antibodies from COVID-19 patients as early as 8 days post-diagnosis and identifies precursor B cells in healthy individuals.

Highly parallelized microfluidic droplet cultivation and prioritization on antibiotic producers from complex natural microbial communities

This paper develops a microfluidic droplet system to cultivate and screen antibiotic-producing bacteria from complex microbial communities, identifying rare strains with antimicrobial activity.

Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001

This study isolates and characterizes Bacillus velezensis DTU001, demonstrating its broad antifungal activity against human and plant pathogens, superior to individual lipopeptides.