Author

T. Hand

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. C. Poholek· 2 shared A. Bhattacharjee· 1 shared A. Burr· 1 shared A. E. Overacre-Delgoffe· 1 shared A. H. Burr· 1 shared A. J. Frazer· 1 shared A. Overacre-Delgoffe· 1 shared A. R. Cillo· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

A. C. Poholek

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3 papers

Recent·Most cited

Maternal Immunoglobulin A regulates the development of the neonatal microbiota and intestinal microbiota-specific CD4+ T cell responses

D. Abbott, A. T. Rai, A. Yang, Y. Cai, S. Fabre, A. J. Frazer, J. D. Deschepper, A. C. Poholek, T. Hand

This study shows that maternal IgA suppresses Enterobacteriaceae colonization and prevents the development of intestinal microbiota-specific CD4+ T cells in neonates.

bioRxiv · Jun 10, 2024 · PreprintImmunology

Excess dietary sugar impairs colonic epithelial regeneration in response to damage.

A. Burr, J. Ji, K. Ozler, O. Eskiocak, B. Yueh, A. V. Menk, A. S. H. Costa, N. Rittenhouse, C. W. Marshall, P. Chiaranunt, L. Mullinax, A. Overacre-Delgoffe, V. S. Cooper, A. C. Poholek, G. M. Delgoffe, , T. Hand

This study shows that high sugar diets impair colonic epithelial regeneration by altering metabolic pathways in intestinal stem cells.

bioRxiv · Aug 18, 2021 · PreprintImmunology

Microbiome-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer.

A. E. Overacre-Delgoffe, A. R. Cillo, H. J. Bumgarner, A. H. Burr, J. T. Tometich, A. Bhattacharjee, T. C. Bruno, D. A. Vignali, T. Hand

The paper shows that introducing an immunogenic commensal bacteria modifies the microbiome to enhance anti-tumor immunity in colorectal cancer by promoting tertiary lymphoid structures and T follicular helper cell activity.

bioRxiv · Jan 27, 2021 · PreprintImmunology